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排序方式: 共有790条查询结果,搜索用时 62 毫秒
781.
Fahmy G. Elsaid Mohamed A. Alshehri Ali A. Shati Mohamed A. Al-Kahtani Ali S. Alsheri Ehab E. Massoud Attalla F. El-kott Haitham I. El-Mekkawy Amira M. Al-Ramlawy Mohamed E. Abdraboh 《Clinical and experimental pharmacology & physiology》2020,47(9):1611-1621
This study investigated the effect of ellagic acid (EA) on SKOV-3 cell growth and invasiveness and tested if the underlying mechanism involves modulating autophagy. Cells were treated with EA in the presence or absence of chloroquine (CQ), an autophagy inhibitor, compound C (CC), an AMPK inhibitor, or an insulin-like growth factor-1 (IGF-1), a PI3K/Akt activator. EA, at an IC50 of 36.6 µmol/L, inhibited cell proliferation, migration, and invasion and induced cell apoptosis in SKOV-3 cells. These events were prevented by CQ. Also, EA increased levels of Beclin-1, ATG-5, LC3I/II, Bax, cleaved caspase-3/8 and reduced those of p62 and Bcl-2 in these cancer cells. Mechanistically, EA decreased levels of p-S6K1 (Thr389) and 4EBP-1 (Thr37/46), two downstream targets of mTORC1, and p-Akt (Thr308) but increased levels of AMPK (Thr172) and p-raptor (Ser792), a natural inhibitor of mTORC1. CC or IGF-1 alone partially prevented the effect of EA on cell survival, cell invasions, and levels of LDH, Beclin-1, and cleaved caspase-3. In conclusion, EA can inhibit SKOV-3 growth, migration, and invasion by activating cytotoxic autophagy mediated by inhibition of mTORC1 and Akt and activation of AMPK. 相似文献
782.
CT Chan RE Reeves R Geller SS Yaghoubi A Hoehne DE Solow-Cordero G Chiosis TF Massoud R Paulmurugan SS Gambhir 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(37):E2476-E2485
Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we developed a dual-luciferase (Renilla and Firefly) reporter system for high-throughput screening (HTS) and monitoring the efficacy of Hsp90 inhibitors in cell culture and live mice. HTS of a 30,176 small-molecule chemical library in cell culture identified a compound, N-(5-methylisoxazol-3-yl)-2-[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio]acetamide (CP9), that binds to Hsp90(α/β) and displays characteristics of Hsp90 inhibitors, i.e., degradation of Hsp90 client proteins and inhibition of cell proliferation, glucose metabolism, and thymidine kinase activity, in multiple cancer cell lines. The efficacy of CP9 in disrupting Hsp90(α/β)/p23 interactions and cell proliferation in tumor xenografts was evaluated by non-invasive, repetitive Renilla luciferase and Firefly luciferase imaging, respectively. At 38 h posttreatment (80 mg/kg × 3, i.p.), CP9 led to selective disruption of Hsp90α/p23 as compared with Hsp90β/p23 interactions. Small-animal PET/CT in the same cohort of mice showed that CP9 treatment (43 h) led to a 40% decrease in (18)F-fluorodeoxyglucose uptake in tumors relative to carrier control-treated mice. However, CP9 did not lead to significant degradation of Hsp90 client proteins in tumors. We performed a structural activity relationship study with 62 analogs of CP9 and identified A17 as the lead compound that outperformed CP9 in inhibiting Hsp90(α/β)/p23 interactions in cell culture. Our efforts demonstrated the power of coupling of HTS with multimodality molecular imaging and led to identification of Hsp90 inhibitors. 相似文献
783.
784.
Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A Patient‐Level Analysis 下载免费PDF全文
785.
786.
Adam G. Starr Paolo F. Caimi PingFu Fu Mira R. Massoud Howard Meyerson Eric D. Hsi 《Hematology (Amsterdam, Netherlands)》2017,22(7):405-411
Objectives and methods: Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin lymphoma. We sought to identify prognostic factors and define outcomes in a cohort of 64 patients with SMZL who were treated at two large academic medical centers in North America in the rituximab era.Results: Over a median follow-up of 37.8 (range 6–167.1) months, Kaplan–Meier estimate of median OS was 156.3 months and median PFS was 52.9 months. On univariate analysis, baseline hemoglobin <12?g/dl was associated with inferior OS (p?=?0.045). High-risk FLIPI score was associated with inferior PFS when compared with intermediate/low risk (p?=?0.05) and marginally significant with regard to OS (p?=?0.056). Splenectomy was not predictive of OS or PFS (p?=?0.563 and 0.937, respectively). Transformation to diffuse large B-cell lymphoma occurred in four (6.3%) patients during the observation period. OS was comparable to contemporaneous cohorts of patients with extranodal and nodal marginal lymphomas and FLIPI score was highly predictive for inferior PFS and OS when all three cohorts were analyzed together.Conclusion: Outcomes of SMZL, in our series, were excellent, with a median OS of >13 years. Low hemoglobin and high-risk FLIPI were associated with inferior outcomes. 相似文献
787.
Asmae Karroum Pezhman Mirshahi Nadia Benabbou Anne-Marie Faussat Jeannette Soria Amu Therwath Massoud Mirshahi Mohamed Hatmi 《Cancer letters》2010
Matrix metalloproteinase-9 (MMP-9) strongly influences tumor development and metastasis. Using resistant (rMCF-7) and sensitive (sMCF-7) breast cancer lines we investigated the role of MMP-9 in cell migration (CM) and tubular network (TN) formation, two processes implied in tumor growth and metastasis. Our data demonstrate that MMP-9 which is critical for CM is necessary but not sufficient for TN formation and suggest a link between MDR1/P-gp and constitutive MMP-9. Both TN formation and CM are dependent on PKC and ERK1/2 pathways. 相似文献
788.
Shirley V. Wang Anton Pottegård William Crown Peter Arlett Darren M. Ashcroft Eric I. Benchimol Marc L. Berger Gracy Crane Wim Goettsch Wei Hua Shaum Kabadi David M. Kern Xavier Kurz Sinead Langan Takahiro Nonaka Lucinda Orsini Susana Perez-Gutthann Simone Pinheiro Nicole Pratt Sebastian Schneeweiss Massoud Toussi Rebecca J. Williams 《Pharmacoepidemiology and drug safety》2023,32(1):44-55
789.